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Article

Absence of a correlation between the presence of a single nucleotide polymorphism in the matrix metalloproteinase 1 promoter and outcome in patients of chondrosarcoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2004

Fong Yi-Chin, Dutton Charyl M, Cha Stephen S, Garamszegi Nandor, Sim Franklin H, Scully Sean P

Abstract excerpt

PURPOSE: Increased levels of matrix metalloproteinase 1 (MMP-1) expression have been associated with poor outcome in chondrosarcoma. The existence of a single nucleotide polymorphism creating an Ets-binding site in the MMP-1 promoter may be one mechanism for elevated MMP-1 transcription. The aim of our study was to identify the prevalence of this single nucleotide polymorphism (SNP) in chondrosarcoma patients, to...

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Identifiers

PMID: 15534109
DOI: 10.1158/1078-0432.CCR-04-0900

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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