Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biological importance of a polymorphic CA sequence within intron 1 of the epidermal growth factor receptor gene (EGFR) in high grade central osteosarcomas.

Genes, chromosomes & cancer - 1 Aug 2008

Kersting Christian, Agelopoulos Konstantin, Schmidt Hartmut, Korsching Eberhard, August Christian, Gosheger Georg, Dirksen Uta, Juergens Heribert, Winkelmann Wilfried, Brandt Burkhard, Bielack Stefan, Buerger Horst, Gebert Carsten

Abstract excerpt

Expression of EGFR in high grade osteosarcomas has been observed to be correlated with an improved prognosis. Yet, the underlying mechanism remained unclear since amplifications of EGFR have rarely been described. Recently, the length of a polymorphic CA repeat located at a 5'-regulatory sequence in the intron 1 of the EGFR gene (SSR I) has been shown to be associated with its basal transcriptional activity. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Dinucleotide Repeats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to EGFR gene

Share to Genes, erbB-1

Share to Introns

Share to Osteosarcoma

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 18464244
DOI: 10.1002/gcc.20571

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biological importance of a polymorphic CA sequence within intron 1 of the epidermal growth factor receptor gene (EGFR) in high grade central osteosarcomas.PMID 18464244Read ↗

Lack of evidence for prognostic value of epidermal growth factor receptor intron-1 CA repeats for oral carcinomas.Semantic proximity Read ↗

Modification of Breast Cancer Risk in Young Women by a Polymorphic Sequence in the egfr GeneSemantic proximity Read ↗

Modulation of EGFR gene transcription by secondary structures, a polymorphic repetitive sequence and mutations--a link between genetics and epigenetics.Semantic proximity Read ↗

Distinct amplification of an untranslated regulatory sequence in the egfr gene contributes to early steps in breast cancer development.Semantic proximity Read ↗

Allelic length of a CA dinucleotide repeat in the egfr gene correlates with the frequency of amplifications of this sequence--first results of an inter-ethnic breast cancer study.Semantic proximity Read ↗

Length and loss of heterozygosity of an intron 1 polymorphic sequence of egfr is related to cytogenetic alterations and epithelial growth factor receptor expression.Semantic proximity Read ↗

EGFR Intron 1 polymorphism in Asian Populations and its correlation with EGFR gene expression and amplification in breast tumor tissues.Semantic proximity Read ↗

Mechanisms of<i>egfr</i>Gene Transcription Modulation: Relationship to Cancer Risk and Therapy ResponseSemantic proximity Read ↗

Epidermal growth factor receptor intron-1 CA repeat polymorphism on protein expression and clinical outcome in Taiwanese oral squamous cell carcinomaSemantic proximity Read ↗

Polymorphisms, mutations, and amplification of the EGFR gene in non-small cell lung cancers.Semantic proximity Read ↗

An epidermal growth factor receptor intron 1 polymorphism mediates response to epidermal growth factor receptor inhibitors.Semantic proximity Read ↗

The status of EGFR CA SSR1 is a potential prognostic factor for patients with oral squamous cell carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.