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Article

TP53 mutations and outcome in osteosarcoma: a prospective, multicenter study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Mar 2005

Wunder Jay S, Gokgoz Nalan, Parkes Robert, Bull Shelley B, Eskandarian Sasha, Davis Aileen M, Beauchamp Chris P, Conrad Ernest U, Grimer Robert J, Healey John H, Malkin David, Mangham D C, Rock Michael J, Bell Robert S, Andrulis Irene L

Abstract excerpt

PURPOSE: Mutations of the TP53 gene have been associated with resistance to chemotherapy as well as poor prognosis in many different malignancies. This is the first prospective study of the prognostic value of somatic TP53 mutations in patients with newly diagnosed extremity osteosarcoma. PATIENT...

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Source

Identifiers

PMID: 15735124
DOI: 10.1200/JCO.2005.04.074

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15735124-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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