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Article

hTERT promoter mutations in chondrosarcomas associate with progression and disease-related mortality.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 2018

Lin Yingbo, Seger Nelly, Chen Yi, Hesla Asle C, Wejde Johan, Ghaderi Mehran, Tsagkozis Panagiotis, Larsson Olle, Haglund Felix

Abstract excerpt

Chondrosarcomas are malignant skeletal tumors with chondroid differentiation. Prognosis is largely dependent on histological grading, which suffer from significant interobserver variability. Telomerase activity and abundant telomerase reverse transcriptase (hTERT) expression has previously been associated with chondrosarcoma grade and metastasis. We therefore analyzed the hTERT promoter in clinicopathologically...

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PMID: 30065261
DOI: 10.1038/s41379-018-0098-3

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