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Article

Changes of the p16 gene but not the p53 gene in human chondrosarcoma tissues

15 Mar 2000

Abstract excerpt

The role of two important tumour suppressor genes, p16 and p53, was evaluated in cartilaginous tumour tissues. Genomic DNA from 22 chondrosarcomas, 5 benign chondroid tumours, 1 sample of reactive proliferative cartilage and 2 samples of normal cartilage were analysed using polymerase chain reaction, single strand conformational polymorphism, DNA sequencing and methylation-specific polymerase chain reaction. The...

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PMID: 10709095
DOI: 10.1002/(sici)1097-0215(20000315)85:6<782::aid-ijc7>3.0.co;2-o

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