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Article

RNAi mediated MMP-1 silencing inhibits human chondrosarcoma invasion

1 Nov 2005

Abstract excerpt

Previous work indicates that matrix metalloproteinase-1 (MMP-1) gene expression is a prognostic factor for local recurrence and metastasis in human chondrosarcoma. The current study evaluates the effects of MMP-1 knock-down via RNA interference on chondrosarcoma metastasis in vitro. Of nine siRNA oligos tested, one showed a 90% inhibitory effect on MMP-1 gene expression. Stable attenuation of MMP-1 in...

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PMID: 15927440
DOI: 10.1016/j.orthres.2005.04.004.1100230633

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