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Article

Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin.

DNA repair - 1 Dec 2013

Krokeide Silje Z, Laerdahl Jon K, Salah Medya, Luna Luisa, Cederkvist F Henning, Fleming Aaron M, Burrows Cynthia J, Dalhus Bjørn, Bjørås Magnar

Abstract excerpt

Base excision repair is the major pathway for removal of oxidative DNA base damage. This pathway is initiated by DNA glycosylases, which recognize and excise damaged bases from DNA. In this work, we have purified the glycosylase domain (GD) of human DNA glycosylase NEIL3. The substrate specificity has been characterized and we have elucidated the catalytic mechanisms. GD NEIL3 excised the hydantoin lesions...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23755964
DOI: 10.1016/j.dnarep.2013.04.026
PMCID: PMC3840045

Genes

NEIL3
NEIL1
NEIL2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin.PMID 23755964Read ↗

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