Article
The relationship between benzo[a]pyrene-induced mutagenesis and carcinogenesis in repair-deficient Cockayne syndrome group B mice.
Cancer research - 15 Oct 2000
Wijnhoven S W, Kool H J, van Oostrom C T, Beems R B, Mullenders L H, van Zeeland A A, van der Horst G T, Vrieling H, van Steeg H
Abstract excerpt
Cockayne syndrome (CS) patients are deficient in the transcription coupled repair (TCR) subpathway of nucleotide excision repair (NER) but in contrast to xeroderma pigmentosum patients, who have a defect in the global genome repair subpathway of NER, CS patients do not have an elevated cancer incidence. To determine to what extent a TCR deficiency affects carcinogen-induced mutagenesis and carcinogenesis, CS...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.