Article
The codon 620 tryptophan allele of the lymphoid tyrosine phosphatase (LYP) gene is a major determinant of Graves' disease.
The Journal of clinical endocrinology and metabolism - 1 Nov 2004
Velaga M R, Wilson V, Jennings C E, Owen C J, Herington S, Donaldson P T, Ball S G, James R A, Quinton R, Perros P, Pearce S H S
Abstract excerpt
The lymphoid tyrosine phosphatase (LYP), encoded by the protein tyrosine phosphatase-22 (PTPN22) gene, is a powerful inhibitor of T cell activation. Recently, a single nucleotide polymorphism (SNP), encoding a functional arginine to tryptophan residue change at LYP codon 620 has been shown to be associated with type 1 diabetes and other autoimmune disorders. We have used a PCR-restriction fragment (XcmI) assay to...
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