Article
Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus.
Diabetes - 1 Nov 2004
Smyth Deborah, Cooper Jason D, Collins Joanne E, Heward Joanne M, Franklyn Jayne A, Howson Joanna M M, Vella Adrian, Nutland Sarah, Rance Helen E, Maier Lisa, Barratt Bryan J, Guja Cristian, Ionescu-Tîrgoviste Constantin, Savage David A, Dunger David B, Widmer Barry, Strachan David P, Ring Susan M, Walker Neil, Clayton David G, Twells Rebecca C J, Gough Stephen C L, Todd John A
Abstract excerpt
In the genetic analysis of common, multifactorial diseases, such as type 1 diabetes, true positive irrefutable linkage and association results have been rare to date. Recently, it has been reported that a single nucleotide polymorphism (SNP), 1858C>T, in the gene PTPN22, encoding Arg620Trp in the lymphoid protein tyrosine phosphatase (LYP), which has been shown to be a negative regulator of T-cell activation, is...
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