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Article

MYC Oncogene Contributions to Release of Cell Cycle Brakes

22 Mar 2019

Abstract excerpt

Promotion of the cell cycle is a major oncogenic mechanism of the oncogene c-MYC (MYC). MYC promotes the cell cycle by not only activating or inducing cyclins and CDKs but also through the downregulation or the impairment of the activity of a set of proteins that act as cell-cycle brakes. This review is focused on the role of MYC as a cell-cycle brake releaser i.e., how MYC stimulates the cell cycle mainly...

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Identifiers

PMID: 30909496
DOI: 10.3390/genes10030244

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