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Article

Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter.

Oncogene - 23 Jan 2003

Wu Siqin, Cetinkaya Cihan, Munoz-Alonso Maria J, von der Lehr Natalie, Bahram Fuad, Beuger Vincent, Eilers Martin, Leon Javier, Larsson Lars-Gunnar

Abstract excerpt

Inhibition of cellular differentiation is one of the well-known biological activities of c-Myc-family proteins. We show here that Myc represses differentiation-induced expression of the cyclin-dependent kinase (CDK) inhibitor p21CIP1 (CDKN1A, p21), known to play an important role in cell fate decisions during growth and differentiation, in hematopoietic cells. Our results demonstrate that the c-Myc-responsive...

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Identifiers

PMID: 12545156
DOI: 10.1038/sj.onc.1206145

Genes

CDKN1A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter.PMID 12545156Read ↗

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