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Article

WNT3 and membrane-associated β-catenin regulate trophectoderm lineage differentiation in human blastocysts

24 Jun 2015

Abstract excerpt

WNT/β-catenin signaling has been described as a crucial regulator of embryonic stem cells and embryogenesis. However, little is known on its role during human preimplantation embryo development, besides the RNA expression of its multiple players. In this study, we performed β-catenin loss- and gain-of-function studies on human preimplantation embryos by adding either Cardamonin or GSK3 inhibitor,...

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PMID: 26108805
DOI: 10.1093/molehr/gav036

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