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Article

Identification of β-catenin binding regions in colon cancer cells using ChIP-Seq

11 May 2010

Abstract excerpt

Deregulation of the Wnt/β-catenin signaling pathway is a hallmark of colon cancer. Mutations in the adenomatous polyposis coli (APC) gene occur in the vast majority of colorectal cancers and are an initiating event in cellular transformation. Cells harboring mutant APC contain elevated levels of the β-catenin transcription coactivator in the nucleus which leads to abnormal expression of genes controlled by...

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PMID: 20460455
DOI: 10.1093/nar/gkq363

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