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Article

APC mutations in colorectal tumours from FAP patients are selected for CtBP-mediated oligomerization of truncated APC.

Human molecular genetics - 15 Sept 2011

Schneikert Jean, Brauburger Katharina, Behrens Jürgen

Abstract excerpt

The germline transmission of a mutation in the adenomatous polyposis coli (APC) gene leads to cancer of the gastro-intestinal tract upon somatic inactivation of the remaining allele in familial adenomatous polyposis (FAP) patients. APC mutations result in truncated products that have primarily lost the ability to properly regulate the level of the transcription factor β-catenin. However, colorectal cancer cells...

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Identifiers

PMID: 21665989
DOI: 10.1093/hmg/ddr273

Genes

APC
FAP

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APC mutations in colorectal tumours from FAP patients are selected for CtBP-mediated oligomerization of truncated APC.PMID 21665989Read ↗

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Contribution of the 15 amino acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal tumours from FAP patients.Semantic proximity Read ↗

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