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Article

DNA amplification method tolerant to sample degradation.

Genome research - 1 Nov 2004

Wang Gang, Maher Elizabeth, Brennan Cameron, Chin Lynda, Leo Christopher, Kaur Manjit, Zhu Penny, Rook Martha, Wolfe Jia Liu, Makrigiorgos G Mike

Abstract excerpt

Despite recent advances in linear whole genome amplification of intact DNA/RNA, amplification of degraded nucleic acids in an unbiased fashion remains a serious challenge for genetic diagnosis. We describe a new whole genome amplification procedure, RCA-RCA (Restriction and Circularization-Aided Rolling Circle Amplification), which retains the allelic differences among degraded amplified genomes while achieving...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15520297
DOI: 10.1101/gr.2813404
PMCID: PMC525695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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