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Article

Self-association and BiP dissociation are not sufficient for activation of the ER stress sensor Ire1.

Journal of cell science - 1 May 2007

Oikawa Daisuke, Kimata Yukio, Kohno Kenji

Abstract excerpt

Ire1 is a type I transmembrane protein located on the endoplasmic reticulum (ER). Upon ER stress, Ire1 releases the ER chaperone BiP and self-associates. This activates Ire1 and triggers the unfolded protein response in the yeast Saccharomyces cerevisiae. We isolated and characterized an Ire1 luminal domain mutant lacking both the N-terminal and the juxtamembrane loosely folded subregions. Although this 'core'...

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Identifiers

PMID: 17452628
DOI: 10.1242/jcs.002808

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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