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Article

LHS1 and SIL1 provide a lumenal function that is essential for protein translocation into the endoplasmic reticulum.

The EMBO journal - 1 Dec 2000

Tyson J R, Stirling C J

Abstract excerpt

Lhs1p is an Hsp70-related chaperone localized in the endoplasmic reticulum (ER) lumen. Deltalhs1 mutant cells are viable but are constitutively induced for the unfolded protein response (UPR). Here, we demonstrate a severe growth defect in Deltaire1Deltalhs1 double mutant cells in which the UPR can no longer be induced. In addition, we have identified a UPR- regulated gene, SIL1, whose overexpression is...

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Source

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Identifiers

PMID: 11101517
DOI: 10.1093/emboj/19.23.6440
PMCID: PMC305876

Genes

SIL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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LHS1 and SIL1 provide a lumenal function that is essential for protein translocation into the endoplasmic reticulum.PMID 11101517Read ↗

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