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Article

A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria.

The Biochemical journal - 15 Mar 2005

Birbes Helene, Luberto Chiara, Hsu Yi-Te, El Bawab Samer, Hannun Yusuf A, Obeid Lina M

Abstract excerpt

We recently showed that targeting bSMase (bacterial sphingomyelinase) specifically to mitochondria caused accumulation of ceramide in mitochondria, and induced cytochrome c release and cell death [Birbes, El Bawab, Hannun and Obeid (2001) FASEB J., 15, 2669-2679]. In the present study, we investigated the role of this mitochondrial pool of ceramide in response to a receptor-mediated event, namely TNFalpha (tumour...

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Identifiers

PMID: 15516208
DOI: 10.1042/BJ20041627
PMCID: PMC1134862

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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