Article
The properties of the mitochondrial megachannel in mitoplasts from human colon carcinoma cells are not influenced by Bax.
FEBS letters - 4 Jul 2005
Campello Silvia, De Marchi Umberto, Szabò Ildikò, Tombola Francesco, Martinou Jean-Claude, Zoratti Mario
Abstract excerpt
This paper explores the relationship between Bax and the mitochondrial permeability transition pore (PTP). Isolated human colon tumor (HCT116) Bax- mitochondria exposed to recombinant Bax exhibited a slow, cyclosporin A-sensitive swelling, but only at [Bax]>200 nM. The amount of Bax incorporated was much higher than that found in organelles isolated from HCT116 Bax+ staurosporine- or etoposide-treated apoptotic...
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