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Article

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.

Nature - 7 Mar 1996

Verheij M, Bose R, Lin X H, Yao B, Jarvis W D, Grant S, Birrer M J, Szabo E, Zon L I, Kyriakis J M, Haimovitz-Friedman A, Fuks Z, Kolesnick R N

Abstract excerpt

The induction of programmed cell death, or apoptosis, involves activation of a signalling system, many elements of which remain unknown. The sphingomyelin pathway, initiated by hydrolysis of the phospholipid sphingomyelin in the cell membrane to generate the second messenger ceramide, is thought to mediate apoptosis in response to tumour-necrosis factor (TNF)-alpha, to Fas ligand and to X-rays. It is not known...

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Identifiers

PMID: 8598911
DOI: 10.1038/380075a0

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.PMID 8598911Read ↗

Serine palmitoyltransferase: role in apoptotic de novo ceramide synthesis and other stress responses.Semantic proximity Read ↗

Evidence for the association of ultraviolet-C and H(2)O(2)-induced apoptosis with acid sphingomyelinase activation.Semantic proximity Read ↗

Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis.Semantic proximity Read ↗

Modulation of DNA Damage Response by Sphingolipid Signaling: An Interplay that Shapes Cell FateSemantic proximity Read ↗

Distinct apoptotic phenotypes induced by radiation and ceramide in both p53-wild-type and p53-mutated lymphoblastoid cells.Semantic proximity Read ↗

Lactosylceramide is required in apoptosis induced by N-Smase.Semantic proximity Read ↗

JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD.Semantic proximity Read ↗

The C-terminal activation domain of the STAT-1 transcription factor is necessary and sufficient for stress-induced apoptosis.Semantic proximity Read ↗

Phosphorylation of specific serine residues in the PKR activation domain of PACT is essential for its ability to mediate apoptosis.Semantic proximity Read ↗

Fas, ceramide and serum withdrawal induce apoptosis via a common pathway in a type II Jurkat cell line.Semantic proximity Read ↗

Serine 58 of 14-3-3zeta is a molecular switch regulating ASK1 and oxidant stress-induced cell death.Semantic proximity Read ↗

Actin-induced hyperactivation of the Ras signaling pathway leads to apoptosis in Saccharomyces cerevisiae.Semantic proximity Read ↗

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