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Article

Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity.

Proceedings of the National Academy of Sciences of the United States of America - 29 Aug 1995

Tepper C G, Jayadev S, Liu B, Bielawska A, Wolff R, Yonehara S, Hannun Y A, Seldin M F

Abstract excerpt

Triggering of the Fas/APO-1 cell-surface receptor induces apoptosis through an uncharacterized chain of events. Exposure of Fas-sensitive cells to an agonist monoclonal antibody induced cell death and a 200-300% elevation in endogenous levels of the sphingolipid ceramide, a proposed intracellular mediator of apoptosis. In contrast, similar treatment of Fas-resistant cells caused insignificant changes in ceramide...

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Identifiers

PMID: 7545303
DOI: 10.1073/pnas.92.18.8443
PMCID: PMC41173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity.PMID 7545303Read ↗

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