Article
Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity.
Proceedings of the National Academy of Sciences of the United States of America - 29 Aug 1995
Tepper C G, Jayadev S, Liu B, Bielawska A, Wolff R, Yonehara S, Hannun Y A, Seldin M F
Abstract excerpt
Triggering of the Fas/APO-1 cell-surface receptor induces apoptosis through an uncharacterized chain of events. Exposure of Fas-sensitive cells to an agonist monoclonal antibody induced cell death and a 200-300% elevation in endogenous levels of the sphingolipid ceramide, a proposed intracellular mediator of apoptosis. In contrast, similar treatment of Fas-resistant cells caused insignificant changes in ceramide...
Topics
- Antigens, Surface
- Apoptosis
- Cell Line
- Cell Survival
- Ceramides
- Enzyme Activation
- Hydrolysis
- Phenotype
- Protein Kinase C
- Sphingomyelins
- fas Receptor