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Article

Site-specific recombination determined by I-SceI, a mitochondrial group I intron-encoded endonuclease expressed in the yeast nucleus.

Genetics - 1 Mar 1992

Plessis A, Perrin A, Haber J E, Dujon B

Abstract excerpt

The Saccharomyces cerevisiae mitochondrial endonuclease I-SceI creates a double-strand break as the initiating step in the gene conversional transfer of the omega+ intron to omega- DNA. We have expressed a galactose-inducible synthetic I-SceI gene in the nucleus of yeast that also carries the I-SceI recognition site on a plasmid substrate. We find that the galactose-induced I-SceI protein can be active in the...

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Identifiers

PMID: 1551570
DOI: 10.1093/genetics/130.3.451
PMCID: PMC1204864

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