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Article

Whole-cell and single-channel analysis of P-type calcium currents in cerebellar Purkinje cells of leaner mutant mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Oct 1998

Dove L S, Abbott L C, Griffith W H

Abstract excerpt

The leaner (tgla) mutation in mice results in severe ataxia and an overt neurodegeneration of the cerebellum. Positional cloning has revealed that the tgla mutation occurs in a gene encoding the voltage-activated calcium channel alpha1A subunit. The alpha1A subunit is highly expressed in the cerebellum and is thought to be the pore-forming subunit of P- and Q-type calcium channels. In this study we used both...

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PMID: 9742139
PMCID: PMC6793003

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Whole-cell and single-channel analysis of P-type calcium currents in cerebellar Purkinje cells of leaner mutant mice.PMID 9742139Read ↗

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