Article
Whole-cell and single-channel analysis of P-type calcium currents in cerebellar Purkinje cells of leaner mutant mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Oct 1998
Dove L S, Abbott L C, Griffith W H
Abstract excerpt
The leaner (tgla) mutation in mice results in severe ataxia and an overt neurodegeneration of the cerebellum. Positional cloning has revealed that the tgla mutation occurs in a gene encoding the voltage-activated calcium channel alpha1A subunit. The alpha1A subunit is highly expressed in the cere...
Topics
- Animals
- Body Weight
- Calcium Channel Blockers
- Calcium Channels
- Calcium Channels, N-Type
- Electric Conductivity
- Electric Stimulation
- Female
- Ion Channel Gating
- Male
- Membrane Potentials
- Mice
- Mice, Inbred C57BL
- Mice, Neurologic Mutants
- Mutation
- Nifedipine
- Patch-Clamp Techniques
- Peptides