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Article

Oct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis

16 Sept 2004

Abstract excerpt

The Oct3/4 gene, a POU family transcription factor, has been noted as being specifically expressed in embryonic stem cells and in tumor cells but not in cells of differentiated tissues. With the ability to isolate adult human stem cells it became possible to test for the expression of Oct3/4 gene in adult stem cells and to test the stem cell theory of carcinogenesis. Using antibodies and PCR primers we tested...

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PMID: 15513931
DOI: 10.1093/carcin/bgh321

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