Regulation of Leukocyte-Endothelium Interaction by Fibrinogen

Abstract excerpt

Introduction The binding of neutrophils and mononuclear cells to vascular endothelium is an essential prerequisite in maintaining effective immune-inflammatory responses. This process has been unraveled as a regulated “adhesion cascade” that involves the expression of multiple adhesion receptors of the integrin, selectin, and immunoglobulin gene superfamilies on both cell types. These adhesive interactions are...

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