Article
Expression of the retinoblastoma gene product in bladder carcinoma cells associates with a low frequency of tumor formation.
Cancer research - 1 Apr 1992
Goodrich D W, Chen Y, Scully P, Lee W H
Abstract excerpt
Upon inactivation of both alleles of the retinoblastoma gene (RB), individuals develop the intraocular eye tumor, retinoblastoma. The gene encodes a Mr 110,000 phosphorylated nuclear protein that may be involved in regulation of the cell cycle. Besides retinoblastoma, mutations of the gene have been detected in several other types of tumors, including bladder carcinoma. Up to one-third of bladder carcinomas may...
Topics
- Alleles
- Blotting, Western
- Cell Division
- Cell Line
- Gene Expression
- Genes, Retinoblastoma
- Humans
- Kinetics
- Molecular Weight
- Retinoblastoma Protein
- Tumor Cells, Cultured