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Article

CDK4/6 Inhibition Controls Proliferation of Bladder Cancer and Transcription of RB1

28 Aug 2015

Abstract excerpt

PURPOSE: The retinoblastoma signaling network is frequently altered in advanced bladder cancer. We investigated the potential of CDK4/6 as a therapeutic target and determined biomarkers for patient stratification. MATERIALS AND METHODS: Genetic alterations were analyzed using public databases, including TCGA (The Cancer Genome Atlas), COSMIC (Catalogue of Somatic Mutations in Cancer) and CCLE (Cancer Cell Line...

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Identifiers

PMID: 26318986
DOI: 10.1016/j.juro.2015.08.082

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