Article
The retinoblastoma gene functions as a growth and tumor suppressor in human bladder carcinoma cells.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jun 1991
Takahashi R, Hashimoto T, Xu H J, Hu S X, Matsui T, Miki T, Bigo-Marshall H, Aaronson S A, Benedict W F
Abstract excerpt
The product of the human retinoblastoma gene (RB) is a nuclear phosphoprotein that is thought to function as a tumor suppressor. Mutations of RB frequently occur in human bladder carcinoma. To investigate the significance of the functional loss of this gene in bladder cancer, an RB expression pla...
Topics
- Actins
- Animals
- Base Sequence
- Blotting, Northern
- Genes, Suppressor
- Humans
- Immunohistochemistry
- Mice
- Mice, Nude
- Molecular Sequence Data
- Mutation
- Phenotype