Article
The retinoblastoma gene functions as a growth and tumor suppressor in human bladder carcinoma cells.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jun 1991
Takahashi R, Hashimoto T, Xu H J, Hu S X, Matsui T, Miki T, Bigo-Marshall H, Aaronson S A, Benedict W F
Abstract excerpt
The product of the human retinoblastoma gene (RB) is a nuclear phosphoprotein that is thought to function as a tumor suppressor. Mutations of RB frequently occur in human bladder carcinoma. To investigate the significance of the functional loss of this gene in bladder cancer, an RB expression plasmid (pBARB) under control of the human beta-actin promoter was transfected into the bladder carcinoma cell line HTB9,...
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