Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm.

European journal of biochemistry - 1 Nov 2004

Katoh Yoshiko, Takemori Hiroshi, Min Li, Muraoka Masaaki, Doi Junko, Horike Nanao, Okamoto Mitsuhiro

Abstract excerpt

Salt-inducible kinase-1 (SIK1) is phosphorylated at Ser577 by protein kinase A in adrenocorticotropic hormone-stimulated Y1 cells, and the phospho-SIK1 translocates from the nucleus to the cytoplasm. The phospho-SIK1 is dephosphorylated in the cytoplasm and re-enters the nucleus several hours lat...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3-L1 Cells
Share to Active Transport, Cell Nucleus
Share to Arginine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic AMP-Dependent Protein Kinases

Share to Cyclic AMP Response Element-Binding Protein

Share to Immunoprecipitation

Share to Lysine

Share to Nuclear Localization Signals

Source

Identifiers

PMID: 15511237
DOI: 10.1111/j.1432-1033.2004.04372.x

Genes

SIK1
SIK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15511237-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm.PMID 15511237Read ↗

Drosophila salt-inducible kinase (SIK) regulates starvation resistance through cAMP-response element-binding protein (CREB)-regulated transcription coactivator (CRTC).Semantic proximity Read ↗

Salt-inducible kinase inhibition promotes the adipocyte thermogenic program and adipose tissue browningSemantic proximity Read ↗

Suppression of gluconeogenic gene transcription by SIK1-induced ubiquitination and degradation of CRTC1.Semantic proximity Read ↗

Activation of cAMP-dependent protein kinase increases the protein level of steroidogenic factor-1.Semantic proximity Read ↗

Protein-kinase-A-dependent activator in transcription factor CREB reveals new role for CREM repressors.Semantic proximity Read ↗

Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A.Semantic proximity Read ↗

The ways in which hormones change cyclic adenosine 3',5'-monophosphate-dependent protein kinase subunits, and how such changes affect cell behavior.Semantic proximity Read ↗

Transcription of the human sodium channel SCN1A gene is repressed by a scaffolding protein RACK1.Semantic proximity Read ↗

Split pleckstrin homology domain-mediated cytoplasmic-nuclear localization of PI3-kinase enhancer GTPase.Semantic proximity Read ↗

VRK1 phosphorylates CREB and mediates <i>CCND1</i> expressionSemantic proximity Read ↗

Cyclic AMP- and cyclic GMP-dependent protein kinases differ in their regulation of cyclic AMP response element-dependent gene transcription.Semantic proximity Read ↗

A PIT-1 homeodomain mutant blocks the intranuclear recruitment of the CCAAT/enhancer binding protein alpha required for prolactin gene transcription.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.