Transcription of the human sodium channel SCN1A gene is repressed by a scaffolding protein RACK1.

Abstract excerpt

Voltage-gated sodium channel α subunit type I (Nav1.1, encoded by SCN1A gene) plays a critical role in the initiation of action potential in the central nervous system. Downregulated expression of SCN1A is believed to be associated with epilepsy. Here, we found that the SCN1A promoter (P1c), located at the 5' untranslated exon 1c, drove the reporter gene expression in human NT2 cells, and a region between nt +53...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Differentiation
• Share to GTP-Binding Proteins