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Article

A genetic algorithm approach to detecting lineage-specific variation in selection pressure.

Molecular biology and evolution - 1 Mar 2005

Pond Sergei L Kosakovsky, Frost Simon D W

Abstract excerpt

The ratio of nonsynonymous (dN) to synonymous (dS) substitution rates, omega, provides a measure of selection at the protein level. Models have been developed that allow omega to vary among lineages. However, these models require the lineages in which differential selection has acted to be specified a priori. We propose a genetic algorithm approach to assign lineages in a phylogeny to a fixed number of different...

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PMID: 15509724
DOI: 10.1093/molbev/msi031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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