Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bayesian estimation of positively selected sites.

Journal of molecular evolution - 1 Jun 2004

Huelsenbeck John P, Dyer Kelly A

Abstract excerpt

In protein-coding DNA sequences, historical patterns of selection can be inferred from amino acid substitution patterns. High relative rates of nonsynonymous to synonymous changes (omega = dN/dS) are a clear indicator of positive, or directional, selection, and several recently developed methods attempt to distinguish these sites from those under neutral or purifying selection. One method uses an empirical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Vertebrates
Share to Bayes Theorem
Share to Codon

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Globins

Share to Likelihood Functions

Share to Models, Genetic

Share to Selection, Genetic

Source

Identifiers

PMID: 15461423
DOI: 10.1007/s00239-004-2588-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bayesian estimation of positively selected sites.PMID 15461423Read ↗

Bayes empirical bayes inference of amino acid sites under positive selection.Semantic proximity Read ↗

Accuracy and power of bayes prediction of amino acid sites under positive selection.Semantic proximity Read ↗

Detecting positively selected amino acid sites using posterior predictive P-values.Semantic proximity Read ↗

Identifying Lineage-specific Targets of Darwinian Selection by a Bayesian Analysis of Genomic Polymorphisms and Divergence from Multiple SpeciesSemantic proximity Read ↗

Erasing errors due to alignment ambiguity when estimating positive selection.Semantic proximity Read ↗

Selectome update: quality control and computational improvements to a database of positive selection.Semantic proximity Read ↗

Inference of mutation parameters and selective constraint in mammalian coding sequences by approximate Bayesian computation.Semantic proximity Read ↗

A genetic algorithm approach to detecting lineage-specific variation in selection pressure.Semantic proximity Read ↗

Statistical properties of the branch-site test of positive selection.Semantic proximity Read ↗

A method for inferring the rate of occurrence and fitness effects of advantageous mutations.Semantic proximity Read ↗

Extensively Parameterized Mutation-Selection Models Reliably Capture Site-Specific Selective Constraint.Semantic proximity Read ↗

Maximum likelihood and Bayesian methods for estimating the distribution of selective effects among classes of mutations using DNA polymorphism data.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.