[Multi-drug resistant Mycobacterium leprae from patients with leprosy].

doi:10.5025/hansen.73.227

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Article

[Multi-drug resistant Mycobacterium leprae from patients with leprosy].

Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association - 1 Sept 2004

Maeda Shinji

Abstract excerpt

DNA sequences of Mycobacterium leprae in particular regions of the gyrA, rpoB, and folP genes responsible for resistance to new quinolones, rifampicin and dapsone, respectively, were analyzed. Among 88 isolates of M. leprae from leprosy patients in Japan, Haiti, Indonesia, Pakistan, and the Philippines, eleven isolates had mutational changes in 2 genes (resistance to 2 drugs), and 2 isolates (Shinsei-1 and...

Topics

Animals
Base Sequence
DNA Gyrase
DNA-Directed RNA Polymerases
Dapsone
Drug Resistance, Multiple
Humans
Leprostatic Agents
Leprosy
Mutation
Mycobacterium leprae
Ofloxacin
Rifampin

Source

Open in PubMed

Identifiers

PMID: 15508725
DOI: 10.5025/hansen.73.227

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