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Genotypic investigation of Mycobacterium leprae in patients with relapsing leprosy in Mato Grosso, Brazil.

Medical microbiology and immunology - 16 Dec 2025

de Oliveira Neto Roque Rafael, de Castro Moreira Dos Santos Júnior Agenor, Henrique Brenno Vinicius Martins, Gomes Ciro Martins, Damazo Amílcar Sabino

Abstract excerpt

Leprosy is a chronic disease that leads to significant neurological damage and disabilities. Drug resistance is a major challenge in controlling the disease. Mutations in the folP1, rpoB, and gyrA genes can confer resistance to dapsone, rifampicin, and quinolones, respectively. The aim of this study was to identify mutations in these drug-resistance genes in Mycobacterium leprae among patients in the state of...

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PMID: 41400709
DOI: 10.1007/s00430-025-00864-w

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