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Drug Resistance (Dapsone, Rifampicin, Ofloxacin) and Resistance-Related Gene Mutation Features in Leprosy Patients: A Systematic Review and Meta-Analysis.

International journal of molecular sciences - 18 Oct 2022

Li Xiang, Li Guoli, Yang Jing, Jin Guangjie, Shao Yuting, Li Yunhui, Wei Pingmin, Zhang Lianhua

Abstract excerpt

Dapsone (DDS), Rifampicin (RIF) and Ofloxacin (OFL) are drugs recommended by the World Health Organization (WHO) for the treatment of leprosy. In the context of leprosy, resistance to these drugs occurs mainly due to mutations in the target genes (Folp1, RpoB and GyrA). It is important to monitor antimicrobial resistance in patients with leprosy. Therefore, we performed a meta-analysis of drug resistance in...

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Identifiers

PMID: 36293307
DOI: 10.3390/ijms232012443
PMCID: PMC9604410

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