Evidence for Mycobacterium leprae Drug Resistance in a Large Cohort of Leprous Neuropathy Patients from India.

doi:10.4269/ajtmh.19-0390

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Article

Evidence for Mycobacterium leprae Drug Resistance in a Large Cohort of Leprous Neuropathy Patients from India.

The American journal of tropical medicine and hygiene - 1 Mar 2020

Mahajan Niranjan Prakash, Lavania Mallika, Singh Itu, Nashi Saraswati, Preethish-Kumar Veeramani, Vengalil Seena, Polavarapu Kiran, Pradeep-Chandra-Reddy Chevula, Keerthipriya Muddasu, Mahadevan Anita, Yasha Tagaduru Chickabasaviah, Nandeesh Bevinahalli Nanjegowda, Gnanakumar Krishnamurthy, Parry Gareth J, Sengupta Utpal, Nalini Atchayaram

Abstract excerpt

Resistance to anti-leprosy drugs is on the rise. Several studies have documented resistance to rifampicin, dapsone, and ofloxacin in patients with leprosy. We looked for point mutations within the folP1, rpoB, and gyrA gene regions of the Mycobacterium leprae genome predominantly in the neural form of leprosy. DNA samples from 77 nerve tissue samples were polymerase chain reaction (PCR)-amplified for M leprae DNA...

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Identifiers

PMID: 31933458
DOI: 10.4269/ajtmh.19-0390
PMCID: PMC7056437

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