Article
Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamily.
The Journal of experimental medicine - 4 Oct 2004
Moir Susan, Malaspina Angela, Pickeral Oxana K, Donoghue Eileen T, Vasquez Joshua, Miller Natalie J, Krishnan Surekha R, Planta Marie A, Turney John F, Justement J Shawn, Kottilil Shyamasundaran, Dybul Mark, Mican JoAnn M, Kovacs Colin, Chun Tae-Wook, Birse Charles E, Fauci Anthony S
Abstract excerpt
Human immunodeficiency virus (HIV) infection leads to numerous perturbations of B cells through mechanisms that remain elusive. We performed DNA microarray, phenotypic, and functional analyses in an effort to elucidate mechanisms of B cell perturbation associated with ongoing HIV replication. 42 genes were up-regulated in B cells of HIV-viremic patients when compared with HIV-aviremic and HIV-negative patients,...
Topics
- Apoptosis
- B-Cell Activation Factor Receptor
- B-Cell Maturation Antigen
- B-Lymphocytes
- Cell Differentiation
- Cell Membrane
- Flow Cytometry
- Gene Expression Profiling
- HIV Infections