Article
Molecular genetics of herpesviruses: a recombinant technology approach.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2005
Knight Jason S, Verma Subhash C, Lan Ke, Robertson Erle S
Abstract excerpt
Herpesvirus genetics have long been hindered by the large size of the typical herpesvirus genome and the consequent recalcitrance of these genomes to manipulation by standard molecular genetics techniques. However, two primary strategies have emerged that allow for the generation of targeted viral mutants. With these mutants, investigators can pursue critical questions regarding the relationship between specific...
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