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Bacterial-Artificial-Chromosome-Based Genome Editing Methods and the Applications in Herpesvirus Research

26 Feb 2023

Abstract excerpt

Herpesviruses are major pathogens that infect humans and animals. Manipulating the large genome is critical for exploring the function of specific genes and studying the pathogenesis of herpesviruses and developing novel anti-viral vaccines and therapeutics. Bacterial artificial chromosome (BAC) technology significantly advanced the capacity of herpesviruses researchers to manipulate the virus genomes. In the...

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PMID: 36985163
DOI: 10.3390/microorganisms11030589

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