Article
Evidence for a newly discovered cellular anti-HIV-1 phenotype.
Nature medicine - 1 Dec 1998
Simon J H, Gaddis N C, Fouchier R A, Malim M H
Abstract excerpt
Animal cells have developed many ways to suppress viral replication, and viruses have evolved diverse strategies to resist these. Here we provide evidence that the virion infectivity factor protein of human immunodeficiency virus type 1 (HIV-1) functions to counteract a newly discovered activity in human cells that otherwise inhibits virus replication. This anti-viral phenotype is shown by human T cells, the...
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