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Article

Evidence of selection on the domesticated ERVWE1 env retroviral element involved in placentation.

Molecular biology and evolution - 1 Oct 2004

Bonnaud Bertrand, Bouton Olivier, Oriol Guy, Cheynet Valérie, Duret Laurent, Mallet François

Abstract excerpt

The human endogenous retrovirus HERV-W multicopy family includes a unique proviral locus, termed ERVWE1, which contains gag and pol pseudogenes and has retained a full-length envelope open reading frame (ORF). This Env protein (syncytin) is a highly fusogenic membrane glycoprotein and has been proposed to be involved in hominoid placental physiology. To track the hallmarks of natural selection acting on the...

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PMID: 15254254
DOI: 10.1093/molbev/msh206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Evidence of selection on the domesticated ERVWE1 env retroviral element involved in placentation.PMID 15254254Read ↗

The endogenous retroviral locus ERVWE1 is a bona fide gene involved in hominoid placental physiologySemantic proximity Read ↗

Differential Evolutionary Fate of an Ancestral Primate Endogenous Retrovirus Envelope Gene, the EnvV Syncytin, Captured for a Function in PlacentationSemantic proximity Read ↗

Comprehensive search for intra- and inter-specific sequence polymorphisms among coding envelope genes of retroviral origin found in the human genome: genes and pseudogenes.Semantic proximity Read ↗

A Retroviral Promoter and a Cellular Enhancer Define a Bipartite Element Which Controls <i>env</i> ERVWE1 Placental ExpressionSemantic proximity Read ↗

The approximately 30-million-year-old ERVPb1 envelope gene is evolutionarily conserved among hominoids and Old World monkeys.Semantic proximity Read ↗

The ancient fusogen EnvP(b)1 is expressed in human tissues and its structure informs the evolution of gammaretrovirus envelope proteinsSemantic proximity Read ↗

Captured retroviral envelope syncytin gene associated with the unique placental structure of higher ruminants.Semantic proximity Read ↗

Retroviruses facilitate the rapid evolution of the mammalian placenta.Semantic proximity Read ↗

Identification and characterization of ERV-W-like sequences in Platyrrhini species provides new insights into the evolutionary history of ERV-W in primatesSemantic proximity Read ↗

Identification of an endogenous retroviral envelope gene with fusogenic activity and placenta-specific expression in the rabbit: a new "syncytin" in a third order of mammalsSemantic proximity Read ↗

The envelope glycoprotein of human endogenous retrovirus type W uses a divergent family of amino acid transporters/cell surface receptors.Semantic proximity Read ↗

An Envelope Glycoprotein of the Human Endogenous Retrovirus HERV-W Is Expressed in the Human Placenta and Fuses Cells Expressing the Type D Mammalian Retrovirus ReceptorSemantic proximity Read ↗

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