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Article

Endogenous Retroviruses Drive Lineage-Specific Regulatory Evolution across Primate and Rodent Placentae

27 Jul 2021

Abstract excerpt

In mammals, the placenta mediates maternal-fetal nutrient and waste exchange and acts in an immunomodulatory way to facilitate maternal-fetal tolerance. The placenta is highly diverse across mammalian species, yet the molecular mechanisms that distinguish the placenta of human from other mammals are not fully understood. Using an interspecies transcriptomic comparison of human, macaque, and mouse late-gestation...

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PMID: 34320657
DOI: 10.1093/molbev/msab223

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