Article
Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family.
Proceedings of the National Academy of Sciences of the United States of America - 2 Nov 2004
Li Yonghong, Nowotny Petra, Holmans Peter, Smemo Scott, Kauwe John S K, Hinrichs Anthony L, Tacey Kristina, Doil Lisa, van Luchene Ryan, Garcia Veronica, Rowland Charles, Schrodi Steve, Leong Diane, Gogic Goran, Chan Joanne, Cravchik Anibal, Ross David, Lau Kit, Kwok Shirley, Chang Sheng-Yung, Catanese Joe, Sninsky John, White Thomas J, Hardy John, Powell John, Lovestone Simon, Morris John C, Thal Leon, Owen Michael, Williams Julie, Goate Alison, Grupe Andrew
Abstract excerpt
Although several genes have been implicated in the development of the early-onset autosomal dominant form of Alzheimer's disease (AD), the genetics of late-onset AD (LOAD) is complex. Loci on several chromosomes have been linked to the disease, but so far only the apolipoprotein E gene has been consistently shown to be a risk factor. We have performed a large-scale single-nucleotide polymorphism (SNP)-based...
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