Article
Protein markers for Alzheimer disease in the frontal cortex and cerebellum.
Neurology - 26 Oct 2004
Verdile G, Gnjec A, Miklossy J, Fonte J, Veurink G, Bates K, Kakulas B, Mehta P D, Milward E A, Tan N, Lareu R, Lim D, Dharmarajan A, Martins R N
Abstract excerpt
OBJECTIVE: To compare proteins related to Alzheimer disease (AD) in the frontal cortex and cerebellum of subjects with early-onset AD (EOAD) with or without presenilin 1 (PS1) mutations with sporadic late-onset AD (LOAD) and nondemented control subjects. METHODS: Immunohistochemistry, immunoblot analysis, and ELISA were used to detect and assess protein levels in brain. RESULTS: In EOAD and to a lesser extent in...
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