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Article

Presenilin-1 C410Y Alzheimer disease plaques contain synaptic proteins.

American journal of Alzheimer's disease and other dementias - 1 Jan 2000

Haleem Kamran, Lippa Carol F, Smith Thomas W, Kowa Hisatomo, Wu Jianlin, Iwatsubo Takeshi

Abstract excerpt

Presenilin-1 (PS-1) mutations are associated with familial Alzheimer's disease (AD). Although beta-amyloid (Abeta) plaques in brain tissue are characteristic of AD patients, space occupying "cotton-wool" plaques (CWPs) lacking dense Abeta cores have also been described in patients with mutations in exon 9 of the PS-1 gene. The composition of CWPs has not been fully described. To better elucidate the composition...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 17545141
DOI: 10.1177/1533317506298051
PMCID: PMC10846028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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