Article
Presenilin 1 interacts with acetylcholinesterase and alters its enzymatic activity and glycosylation.
Molecular and cellular biology - 1 May 2008
Silveyra María-Ximena, Evin Geneviève, Montenegro María-Fernanda, Vidal Cecilio J, Martínez Salvador, Culvenor Janetta G, Sáez-Valero Javier
Abstract excerpt
Presenilin 1 (PS1) plays a critical role in the gamma-secretase processing of the amyloid precursor protein to generate the beta-amyloid peptide, which accumulates in plaques in the pathogenesis of Alzheimer's disease (AD). Mutations in PS1 cause early onset AD, and proteins that interact with PS1 are of major functional importance. We report here the coimmunoprecipitation of PS1 and acetylcholinesterase (AChE),...
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