Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic association between a lymphoid tyrosine phosphatase (PTPN22) and type 1 diabetes.

Diabetes - 1 Mar 2005

Zheng Weipeng, She Jin-Xiong

Abstract excerpt

The lymphoid-specific phosphatase (LYP) encoded by PTPN22 is involved in preventing spontaneous T-cell activation by dephosphorylating and inactivating T-cell receptor-associated Csk kinase. We have genotyped 396 type 1 diabetic patients and 1,178 control subjects of Caucasian descent from north central Florida and report a strong association between type 1 diabetes and a polymorphism (R620W) in the PTPN22 gene....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Mellitus, Type 1
Share to Homozygote
Share to Odds Ratio

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 1

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

Share to Protein Tyrosine Phosphatases

Share to White People

Source

Identifiers

PMID: 15734872
DOI: 10.2337/diabetes.54.3.906

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic association between a lymphoid tyrosine phosphatase (PTPN22) and type 1 diabetes.PMID 15734872Read ↗

Role of PTPN22 in type 1 diabetes and other autoimmune diseases.Semantic proximity Read ↗

A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes.Semantic proximity Read ↗

Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus.Semantic proximity Read ↗

Systematic search for single nucleotide polymorphisms in a lymphoid tyrosine phosphatase gene (PTPN22): association between a promoter polymorphism and type 1 diabetes in Asian populations.Semantic proximity Read ↗

Protein tyrosine phosphatase PTPN22 in human autoimmunity.Semantic proximity Read ↗

The R620W C/T polymorphism of the gene PTPN22 is associated with SLE independently of the association of PDCD1.Semantic proximity Read ↗

A haplotype-based analysis of the PTPN22 locus in type 1 diabetes.Semantic proximity Read ↗

C1858T Polymorphism of Protein Tyrosine Phosphatase Non-receptor Type 22 (PTPN22): an eligible target for prevention of type 1 diabetes?Semantic proximity Read ↗

Targeted Deep Sequencing in Multiple-Affected Sibships of European Ancestry Identifies Rare Deleterious Variants in PTPN22 That Confer Risk for Type 1 Diabetes.Semantic proximity Read ↗

Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetes.Semantic proximity Read ↗

The putative role of the C1858T polymorphism of protein tyrosine phosphatase PTPN22 gene in autoimmunity.Semantic proximity Read ↗

Lymphoid-specific tyrosine phosphatase (Lyp): a potential drug target for treatment of autoimmune diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.