Article
Systematic search for single nucleotide polymorphisms in a lymphoid tyrosine phosphatase gene (PTPN22): association between a promoter polymorphism and type 1 diabetes in Asian populations.
American journal of medical genetics. Part A - 15 Mar 2006
Kawasaki Eiji, Awata Takuya, Ikegami Hiroshi, Kobayashi Tetsuro, Maruyama Taro, Nakanishi Koji, Shimada Akira, Uga Miho, Uga Mho, Kurihara Susumu, Kawabata Yumiko, Tanaka Shoichiro, Kanazawa Yasuhiko, Lee Inkyu, Eguchi Katsumi
Abstract excerpt
The protein tyrosine phosphatase, nonreceptor 22 gene (PTPN22) maps to human chromosome 1p13.3-p13.1 and encodes an important negative regulator of T-cell activation, lymphoid-specific phosphatase (Lyp). Recently, the minor allele of a single-nucleotide polymorphism (SNP) at nucleotide position 1...
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