Article
Cyclin D1 provides a link between development and oncogenesis in the retina and breast.
Cell - 25 Aug 1995
Sicinski P, Donaher J L, Parker S B, Li T, Fazeli A, Gardner H, Haslam S Z, Bronson R T, Elledge S J, Weinberg R A
Abstract excerpt
Mice lacking cyclin D1 have been generated by gene targeting in embryonic stem cells. Cyclin D1-deficient animals develop to term but show reduced body size, reduced viability, and symptoms of neurological impairment. Their retinas display a striking reduction in cell number due to proliferative...
Topics
- Animals
- Cell Differentiation
- Cell Division
- Cyclin D1
- Cyclins
- Female
- Gene Expression Regulation, Developmental
- Gene Targeting
- Male
- Mammary Glands, Animal
- Mice
- Mice, Mutant Strains
- Neoplasms, Experimental
- Oncogene Proteins
- Phenotype